For Alzheimer's disease prevention and cure:
Read the Cunnane papers and the Philips paper, to understand the principles of changing the brain from glucose fuel to ketone fuel. We need to provide the medium chain fatty acids that can be converted to ketones and reduce glucose availability to force the conversion. The conversion happens when in or partially in ketosis. This treatment is based on the theory that the brain loses its ability to use glucose and does not lose its ability to use ketones for energy. The brain can grow more cells and more synapses, but this is slow. It is important that this treatment be started early before a significant part of the brain is lost. If Cunnane is right, amyloid and tau proteins can be thought of as brain scar tissue and not the cause of the problem.
Any attempt to cure Alzheimer’s will only work if the subject has a reason to be intellectually active. There needs to be life purpose or life goals. If the subject is simply in a retirement facility waiting to die, they have no incentive to improve their intellectually capacity. Without life purpose, why not have Alzheimer’s, in later stages it is less stressful.
The Alzheimer’s cure will cure diabetes first. This is the first step and will reduce insulin that would will prevent ketone metabolism.
Take two tablespoons of MCT oil three time a day. MCT oil can have a laxative effect and can cause digestive upset. It may need to be added incrementally.
Use coconut oil, lard or Tallow for cooking.
Take 3 grams of Turmeric each day to clear amyloid plaque proteins from the brain. This is a high dose of turmeric compared to the lifelong plan.
Eat two eggs a day to increase cholesterol availability.
Eliminate added sugars to reduce A1c and Eliminate potatoes, sweet potatoes, rice, corn, bread, carrots, beets, and other starchy foods.
Eat 50 grams of protein a day. This is about two McDonalds patties. An egg has 7 grams of protein. Nuts are from 18 to 25% protein and beans are 8 to 12% protein
Reduce carbohydrates to less than 10% of calories while maintaining fiber intake.
Physical exercise and mental exercise are needed to exercise the brain. Both physical and mental exercise encourage new brain cell formation and synapse formation.
Use intermittent fasting to clear inactive proteins and mitochondria. I recommend 18 hours a day fasting. I fast from 6:00PM to Noon the next day.
This diet may be needed for months to slowly bring back lost cognitive function. Because glucose metabolism has been lost this diet may be needed forever.
Cunnane, S. C., Courchesne-Loyer, A., St-Pierre, V., Vandenberghe, C., Pierotti, T., Fortier, M., … Castellano, C. A. (2016). Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease. Annals of the New York Academy of Sciences, 1367(1), 12–20. https://doi.org/10.1111/NYAS.12999
Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease
Matthew C. L. Phillips https://alzres.biomedcentral.com/articles/10.1186/s13195-021-00783-x
The Ketogenic Diet and Alzheimer's DiseaseH Hersant 1, G Grossberg
https://pubmed.ncbi.nlm.nih.gov/30554068/
How to lose weight without a great deal of willpower, pain, or suffering
Understand the science:
Calorie restriction fails to reduce weight 99% of the time. The metabolic system will slow down to compensate for calorie restriction, at the same time, step up the production of ghrelin, the hunger hormone, and decrease the hormones that would reduce hunger.
Exercise in moderation is an excellent way to be healthy. It is only a minimally effective weight-loss strategy. Exercise increases hunger, and moderate exercise does not significantly increase the metabolic rate. Long-duration high-intensity exercise can be harmful. (Most marathon runners do not age well.)
Fructose is in all added sugars. (table sugar, honey, maple syrup, high fructose corn syrup, and agave) Fructose increases the production of ghrelin. Fructose can not be used by the body for energy and must be converted to fat by the liver. Fat from the liver is stored in a fatty organ surrounding the intestines; this belly fat is the most visible sign of metabolic syndrome. Metabolic syndrome leads to heart disease, fatty liver disease, cancer, diabetes, and Alzheimer’s.
Weight loss requires fat burning and can only happen when the level of insulin in the body is low. Sugars, starches, and proteins keep insulin high.
Steps to effective weight loss:
Eliminate all added sugars: no cookies, fruit juices (not even orange juice), candy, cakes, pies, condiments with added sugar (catsup), etc. Limit fruit to one serving a day. Learn to read food labels to avoid buying foods with added sugar.
Eat a high-fat, low carbohydrate diet. Saturated fats are the best. (See life401.com August 27, 2021 blog post) Fat will reduce apatite. Unfortunately many obese people lose the signal from fat to stop eating. Eat about 0.4 grams of protein per day for each pound of target weight. For those over 65, eat 0.5 grams of additional protein. Read food labels and do the math.
Set a realistic target. A reduction of 10% of your current weight is realistic; after hitting this target and maintaining this weight, you may want to set a new target. Unrealistic targets can lead to disappointment and giving up.
Do not snack. Snacks keep insulin levels high and prevent fat burning.
Use intermittent fasting. Pick a time window and only eat within that window. I fast from 6:00 PM until Noon the next day, an 18 hour fast. Everyone is different; you may only be able to fast for 13 hours a day.
Stay busy. Everyone has found that they have been active on some project and missed a meal. If you follow the above, you will quickly lose several pounds of water. After the first few pounds, the loss will be fat. It will be slow, but it is essential to stay with it. A slow loss over a long time is the most healthful. Cycling loss, gain, loss, gain is deadly.
The basics of eliminating sugar was known in 1863 Banting, W. (1863). Letter on Corpulence, Addressed to the Public. https://archive.org/details/letteroncorpulen00bant/page/10/mode/2up
Lifelong Plan for long and healthy life:
Kick the caffeine habit and only use Caffeine for times when extra physical or mental demands are expected.
It is important to stay hydrated without over drinking and losing too many minerals.
Everyone should eliminate unsaturated vegetable fats like corn oil, soybean oil and other seed oils.
Everyone should eliminate all added sugars. No sugar soft drinks, no cookies, no candy, no sugar containing cereals, no packaged foods with any sugar, no ketchup, no salad dressing with sugar.
Limit starches to 50% of calories or less.
Use MCT oil or olive oil for salads only. Cook with saturated fats Lard, Butter, Coconut oil or Tallow.
Eat at least one serving of cruciform vegetables at least 2 times each week.
Schedule at least 8 hours of sleep and eliminate blue light at least two hours before bed time.
Use a multivitamin, magnesium, calcium with vitamin D, Turmeric, vitamin D3 and vitamin C supplements.
Consume some fish or take an Omega 3 supplement or both.
Exercise at least three times a week. This exercise should include: aerobic, weight bearing and three short periods of high intensity exercise.
Do some intermittent fasting at least once a week. The easiest fasting is 18 hours by only eating from Noon to 6:00 PM each day.
Consume at least 20 grams of fiber per day.
Consume the recommended amount of protein
Limit fruit to one serving a day
For someone that is not diabetic, prediabetic or obese simply doing what is suggested above should be all that is necessary for leading a long life without unnecessary infirmities. Prediabetics and Diabetics need to further reduce carbohydrates.
Age Successfully describes how to age without having all of the infirmities blamed on age. It describes how the author did it wrong, did the research and now at 82 years old lives a life with minimum infirmities. It describes how to minimize, and in most cases eliminate diabetes, heart disease, stroke, degraded cognition, fall fractures, diabetic amputations, cancer, and vision loss. More than one half of all medical care is needed because of lifestyle diseases. There is no need to be in that half. The book covers why calorie restriction, exercise and reduction of dietary fat does not cure obesity and what does. How to cure prediabetes and type 2 diabetes. How to minimize the chance of Alzheimer’s disease. Understand and prevent what causes high blood pressure, , low HDL and high A1c. (High LDL is good not bad)
Click here for a Short summary of Age Successfully.
Robert back packing in Laos in 2016 showing metabolic syndrome belly (Now gone)
Age Successfully
I have included the references so that a reader of the book can simply cut and paste these into the browser and not need to type https://..... each time
References:
AMA. (2016). AMA Adopts Guidance to Reduce Harm from High Intensity Street Lights | American Medical Association. Retrieved November 28, 2018, from https://www.ama-assn.org/ama-adopts-guidance-reduce-harm-high-intensity-street-lights
Arora, T., & Bäckhed, F. (2016). The gut microbiota and metabolic disease: current understanding and future perspectives. Journal of Internal Medicine, 280(4), 339–349. https://doi.org/10.1111/joim.12508
Azevedo, F. R. de, Ikeoka, D., & Caramelli, B. (2013). Effects of intermittent fasting on metabolism in men. Revista Da Associação Médica Brasileira, 59(2), 167–173.
Black, Robert Harrison (2019) https://www.amazon.com/Happy-Intensive-Care-Christian-spirit/dp/109229824X
Banting, W. (1863). Letter on Corpulence, Addressed to the Public. https://archive.org/details/letteroncorpulen00bant/page/10/mode/2up
Baum, J. I., Kim, I. Y., & Wolfe, R. R. (2016, June 8). Protein consumption and the elderly: What is the optimal level of intake? Nutrients. MDPI AG. https://doi.org/10.3390/nu8060359
Brustad, N., Garland, J., Thorsen, J., Sevelsted, A., Krakauer, M., Vinding, R. K., … Chawes, B. L. (2020). Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial. JAMA Pediatrics. https://doi.org/10.1001/jamapediatrics.2019.6083
Cani, P. D., Lecourt, E., Dewulf, E. M., Sohet, F. M., Pachikian, B. D., Naslain, D., … Delzenne, N. M. (2009). Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. The American Journal of Clinical Nutrition, 90(5), 1236–1243. https://doi.org/10.3945/ajcn.2009.28095
Cassidy, S., Thoma, C., Houghton, D., & Trenell, M. I. (n.d.). High-intensity interval training: a review of its impact on glucose control and cardiometabolic health. https://doi.org/10.1007/s00125-016-4106-1
Catenacci, V. A., Pan, Z., Ostendorf, D., Brannon, S., Gozansky, W. S., Mattson, M. P., … Troy Donahoo, W. (2016). A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity, 24(9), 1874–1883. https://doi.org/10.1002/oby.21581
CDC - Fact Sheets- Moderate Drinking - Alcohol. (n.d.). Retrieved October 24, 2018, from https://www.cdc.gov/alcohol/fact-sheets/moderate-drinking.htm
Centers, for Disease Control. (2017). National Diabetes Statistics Report, 2017 Estimates of Diabetes and Its Burden in the United States Background. Retrieved from
Chandalia, M., Garg, A., Lutjohann, D., von Bergmann, K., Grundy, S. M., & Brinkley, L. J. (2000). Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. The New England Journal of Medicine, 342(19), 1392–1398. https://doi.org/10.1056/NEJM200005113421903
Chapuy, M. C., Arlot, M. E., Duboeuf, F., Brun, J., Crouzet, B., Arnaud, S., … Meunier, P. J. (1992). Vitamin D3 and Calcium to Prevent Hip Fractures in Elderly Women. New England Journal of Medicine, 327(23), 1637–1642. https://doi.org/10.1056/NEJM199212033272305
Chatterjee, S., Peters, S. A. E., Woodward, M., Arango, S. M., Batty, G. D., Beckett, N., … Huxley, R. R. (2016). Type 2diabetes as a risk factor for dementia in women compared with men: A pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia. Diabetes Care, 39(2), 300–307. https://doi.org/10.2337/dc15-1588
Chung, H. R. (2014). Iodine and thyroid function. Annals of Pediatric Endocrinology & Metabolism, 19(1), 8–12. https://doi.org/10.6065/apem.2014.19.1.8
Clinic, M. (n.d.). Acute liver failure - Symptoms and causes - Mayo Clinic. Retrieved March 22, 2020, from https://www.mayoclinic.org/diseases-conditions/acute-liver-failure/symptoms-causes/syc-20352863
Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., … Tate, D. F. (2016, November 1). Physical activity/exercise and diabetes: A position statement of the American Diabetes Association. Diabetes Care. American Diabetes Association Inc. https://doi.org/10.2337/dc16-1728
Cole, G. M., & Frautschy, S. A. (2010). DHA May Prevent Age-Related Dementia. The Journal of Nutrition, 140(4), 869–874. https://doi.org/10.3945/jn.109.113910
Croteau, E., Castellano, C. A., Fortier, M., Bocti, C., Fulop, T., Paquet, N., & Cunnane, S. C. (2018). A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer’s disease. Experimental Gerontology, 107, 18–26. https://doi.org/10.1016/j.exger.2017.07.004
Cunnane, S. C., Courchesne-Loyer, A., St-Pierre, V., Vandenberghe, C., Pierotti, T., Fortier, M., … Castellano, C.-A. (2016). Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease. Annals of the New York Academy of Sciences, 1367(1), 12–20. https://doi.org/10.1111/nyas.12999
Cunnane, S. C., Courchesne-Loyer, A., Vandenberghe, C., St-Pierre, V., Fortier, M., Hennebelle, M., … Castellano, C. A. (2016). Can ketones help rescue brain fuel supply in later life? Implications for cognitive health during aging and the treatment of alzheimer’s disease. Frontiers in Molecular Neuroscience, 9(JUL). https://doi.org/10.3389/fnmol.2016.00053
D, S., D, T., A, S., & I V, A. (2016). A SYSTEMATIC REVIEW OF NATURAL TOXINS IN FOOD PLANTS. International Journal of Research in Ayurveda & Pharmacy, 7(2), 52–57. https://doi.org/10.7897/2277-4343.07256
Dalenberg, J. R., Patel, B. P., Denis, R., Veldhuizen, M. G., Nakamura, Y., Vinke, P. C., … Small, D. M. (2020). Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans. Cell Metabolism, 31(3), 493-502.e7. https://doi.org/10.1016/j.cmet.2020.01.014
Dannemann, M., & Kelso, J. (2017). The Contribution of Neanderthals to Phenotypic Variation in Modern Humans. American Journal of Human Genetics, 101(4), 578–589. https://doi.org/10.1016/j.ajhg.2017.09.010
Dashti, H. M., Mathew, T. C., Hussein, T., Asfar, S. K., Behbahani, A., Khoursheed, M. A., … Al-Zaid, N. S. (2004). Long-term effects of a ketogenic diet in obese patients. Experimental and Clinical Cardiology, 9(3), 200–205.
Desai, S. D. (n.d.). Amino acids degradation and synthesis. https://www.medschool.lsuhsc.edu/biochemistry/Courses/Biochemistry201/Desai/Amino%20acid%20Metabolism%20October%201%20Revised,2010.pdf
Dehghan, M., Mente, A., Zhang, X., Swaminathan, S., Li, W., Mohan, V., … Mapanga, R. (2017). Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study. The Lancet, 390(10107), 2050–2062. https://doi.org/10.1016/S0140-6736(17)32252-3
de la Rubia Ortí JE1, García-Pardo MP2, Drehmer E1, Sancho Cantus D3, Julián Rochina M4, Aguilar MA5, H. Y. I. (n.d.). Improvement of Main Cognitive Functions in Patients with Alzheimer’s Disease after Treatment with Coconut Oil Enriched Mediterranean Diet: A Pilot ... - PubMed - NCBI. Retrieved April 27, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/30056419
Epilepsy. (n.d.). Ketogenic Diet | Epilepsy Foundation. Retrieved November 3, 2019, from https://www.epilepsy.com/learn/treating-seizures-and-epilepsy/dietary-therapies/ketogenic-diet
Felitti, V. (n.d.). The Adverse Childhood Experiences Study. https://www.ajpmonline.org/article/S0749-3797(98)00017-8/fulltext
Fernando, W. M. A. D. B., Martins, I. J., Goozee, K. G., Brennan, C. S., Jayasena, V., & Martins, R. N. (2015). The role of dietary coconut for the prevention and treatment of Alzheimer’s disease: potential mechanisms of action. The British Journal of Nutrition, 114(1), 1–14. https://doi.org/10.1017/S0007114515001452
Fettke, G. (n.d.). Dr. Gary Fettke - “A ‘Nutritional’ model of Inflammation & Modern Disease” - YouTube. Retrieved October 20, 2019, from https://www.youtube.com/watch?v=KybOPCB2Qd4
Fortier, M., Castellano, C.-A., Croteau, E., Langlois, F., Bocti, C., St-Pierre, V., … Cunnane, S. C. (2019). A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment. Alzheimer’s & Dementia, 15(5), 625–634. https://doi.org/10.1016/j.jalz.2018.12.017
Fong, J., & Khan, A. (2012). Hypocalcemia: Updates in diagnosis and management for primary care. Canadian Family Physician, 58(2), 158. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279267/
Foster-Schubert, K. E., Alfano, C. M., Duggan, C. R., Xiao, L., Campbell, K. L., Kong, A., … McTiernan, A. (2012). Effect of Diet and Exercise, Alone or Combined, on Weight and Body Composition in Overweight-to-Obese Postmenopausal Women. Obesity, 20(8), 1628–1638. https://doi.org/10.1038/oby.2011.76
Fryar, Cheryl D, Carroll Margeret D., Ogden, C. l. (n.d.). Products - Health E Stats - Overweight, Obesity, and Extreme Obesity Among Adults 2011-2012. Retrieved November 5, 2019, from https://www.cdc.gov/nchs/data/hestat/obesity_adult_11_12/obesity_adult_11_12.htm
Fung, J. (n.d.-a). Fasting for weight reduction May 2019 https://www.youtube.com/watch?v=ETkwZIi3R7w
Fung, J. (n.d.-b). The Roots of the Obesity Epidemic - YouTube. Retrieved October 20, 2019, from https://www.youtube.com/watch?v=q8BGYhreaco
Furmli, S., Elmasry, R., Ramos, M., & Fung, J. (2018). Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin. BMJ Case Reports, 2018, bcr-2017-221854. https://doi.org/10.1136/bcr-2017-221854
Gardner, C. D., & Kraemer, H. C. (1995). Monounsaturated versus polyunsaturated dietary fat and serum lipids. A meta-analysis. Arteriosclerosis, Thrombosis, and Vascular Biology, 15(11), 1917–1927. https://doi.org/10.1161/01.atv.15.11.1917
Gaziano, J. M., Sesso, H. D., Christen, W. G., Bubes, V., Smith, J. P., MacFadyen, J., … Buring, J. E. (2012). Multivitamins in the prevention of cancer in men: The physicians’ health study II randomized controlled trial. JAMA - Journal of the American Medical Association, 308(18), 1871–1880. https://doi.org/10.1001/jama.2012.14641
Gene, E. (n.d.). Mortality Rate Higher After Stem Cell Transplant When Gut Bacteria Diversity Is Low. Retrieved March 22, 2020, from https://www.medscape.com/viewarticle/925802?src=wnl_edit_tpal&uac=362670CN&impID=2294941&faf=1
Gillman, M. W. (1997). Inverse Association of Dietary Fat With Development of Ischemic Stroke in Men. JAMA: The Journal of the American Medical Association, 278(24), 2145. https://doi.org/10.1001/jama.1997.03550240035030
Giorgino, F., Laviola, L., & Eriksson, J. W. (2005). Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies. Acta Physiologica Scandinavica, 183(1), 13–30. https://doi.org/10.1111/j.1365-201X.2004.01385.x
Gopinath, B., Flood, V. M., Kifley, A., Louie, J. C. Y., & Mitchell, P. (2016). Association Between Carbohydrate Nutrition and Successful Aging Over 10 Years. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(10), 1335–1340. https://doi.org/10.1093/gerona/glw091
Graham, J. P., Boland, J. J., & Silbergeld, E. (2007). Growth Promoting Antibiotics in Food Animal Production: An Economic Analysis. Public Health Reports, 122(1), 79. https://doi.org/10.1177/003335490712200111
Grajower, M. M., & Horne, B. D. (2019). Clinical management of intermittent fasting in patients with diabetes mellitus. Nutrients, 11(4). https://doi.org/10.3390/nu11040873
Greve, J., Schultz-Nielsen, M. L., & Tekin, E. (2017). Fetal malnutrition and academic success: Evidence from Muslim immigrants in Denmark. Economics of Education Review, 60, 20–35. https://doi.org/10.1016/j.econedurev.2017.07.008
Halberg, N., Henriksen, M., Söderhamn, N., Stallknecht, B., Ploug, T., Schjerling, P., & Dela, F. (2005). Effect of intermittent fasting and refeeding on insulin action in healthy men. Journal of Applied Physiology, 99(6), 2128–2136. https://doi.org/10.1152/japplphysiol.00683.2005
Hall-Flavin, D. K. (n.d.). Caffeine and depression: Is there a link? - Mayo Clinic. Retrieved October 19, 2019, from https://www.mayoclinic.org/diseases-conditions/depression/expert-answers/caffeine-and-depression/faq-20057870
Hansen, J. (2017). Night Shift Work and Risk of Breast Cancer. Current Environmental Health Reports, 4(3), 325–339. https://doi.org/10.1007/s40572-017-0155-y
Hare, David L. Cardiovascular disease and depression https://academic.oup.com/eurheartj/article/35/21/1365/582931
Heather, R. (n.d.). What Are Cruciferous Vegetables: A Complete List Of Cruciferous Vegetables. Retrieved March 22, 2020, from https://www.gardeningknowhow.com/edible/vegetables/vgen/cruciferous-vegetables.htm
Henderson, S. T. (2008). Ketone Bodies as a Therapeutic for Alzheimer’s Disease. Neurotherapeutics, 5(3), 470–480. https://doi.org/10.1016/j.nurt.2008.05.004
Henderson, S. T., & Poirier, J. (2011). Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer’s disease; a randomized, double-blind, placebo-controlled study. BMC Medical Genetics, 12(1), 137. https://doi.org/10.1186/1471-2350-12-137
Hibbeln JR, Northstone K, Evans J, G. J. (2018). Vegetarian diets and depressive symptoms among men. Journal of Affective Disorders (Vol. 225). https://doi.org/10.1016/j.jad.2017.07.051
Higdon, J. V., Delage, B., Williams, D. E., & Dashwood, R. H. (2007, March). Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacological Research. NIH Public Access. https://doi.org/10.1016/j.phrs.2007.01.009
Holzman, D. C. (2010). What’s in a color? The unique human health effect of blue light. Environmental Health Perspectives, 118(1), A22-7. https://doi.org/10.1289/ehp.118-a22
Imhann, F., Bonder, M. J., Vila, A. V., Fu, J., Mujagic, Z., Vork, L., … Zhernakova, A. (2016). Proton pump inhibitors affect the gut microbiome. Gut, 65(5), 740–748. https://doi.org/10.1136/gutjnl-2015-310376
Jackson, C. L., Redline, S., & Emmons, K. M. (2015). Sleep as a Potential Fundamental Contributor to Disparities in Cardiovascular Health. Annual Review of Public Health, 36(1), 417–440. https://doi.org/10.1146/annurev-publhealth-031914-122838
JAMA https://jamanetwork.com/journals/jama/article-abstract/2759201
Jelleyman, C., Yates, T., O’Donovan, G., Gray, L. J., King, J. A., Khunti, K., & Davies, M. J. (2015, November 1). The effects of high-intensity interval training on glucose regulation and insulin resistance: A meta-analysis. Obesity Reviews. Blackwell Publishing Ltd. https://doi.org/10.1111/obr.12317
Jorde, R., Mathiesen, E. B., Rogne, S., Wilsgaard, T., Kjærgaard, M., Grimnes, G., & Schirmer, H. (2015). Vitamin D and cognitive function: The Tromsø Study. Journal of the Neurological Sciences, 355(1–2), 155–161. https://doi.org/10.1016/j.jns.2015.06.009
Kalantar-Zadeh Kamyar, Kramer, HollyM. (n.d.). High-Protein Diet is Bad for Kidney Health. Retrieved March 21, 2020, from https://www.medscape.com/viewarticle/924423?src=wnl_edit_tpal&uac=362670CN&impID=2283951&faf=1
Kalra Sanjay, Gupta Anu, M. T. S. B. (2020). Prevention of Diabetes Dementia – touchENDOCRINOLOGY. Retrieved March 31, 2020, from https://www.touchendocrinology.com/insight/prevention-of-diabetes-dementia/
Kalantar-Zadeh Kamyar, Kramer, HollyM. (n.d.). High-Protein Diet is Bad for Kidney Health. Retrieved March 21, 2020, from https://www.medscape.com/viewarticle/924423?src=wnl_edit_tpal&uac=362670CN&impID=2283951&faf=1
Kane, M.D., R. L., Butler, Ph.D., M.B.A., M., & Fink, M.D., M.P.H., H. A. (2017). Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia. https://doi.org/10.23970/AHRQEPCCER188
Kennel, K. A., Drake, M. T., & Hurley, D. L. (2010). Vitamin D deficiency in adults: when to test and how to treat. Mayo Clinic Proceedings, 85(8), 752–757; quiz 757–758. https://doi.org/10.4065/mcp.2010.0138
Kottusch, P., Tillmann, M., & Püschel, K. (n.d.). [Survival time without food and drink]. Archiv Fur Kriminologie, 224(5–6), 184–191. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20069776
Kummerow, F. A. (2013). Interaction between sphingomyelin and oxysterols contributes to atherosclerosis and sudden death. American Journal of Cardiovascular Disease, 3(1), 17–26. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23459228
Lande, K. E., & Sperry, W. M. (1936). Human atherosclerosis in relation to the cholesterol content of the blood serum. Arch. Pathol., 22, 301–312.
Lavie, C. J., Ozemek, C., Carbone, S., Katzmarzyk, P. T., & Blair, S. N. (2019). Sedentary Behavior, Exercise, and Cardiovascular Health. Circulation Research, 124(5), 799–815. https://doi.org/10.1161/CIRCRESAHA.118.312669
Leung, C., Rivera, L., Furness, J. B., & Angus, P. W. (2016). The role of the gut microbiota in NAFLD. Nat. Rev. Gastroenterol. Hepatol., 13, 412–425.
Levine, M. E., Suarez, J. A., Brandhorst, S., Balasubramanian, P., Cheng, C. W., Madia, F., … Longo, V. D. (2014). Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metabolism, 19(3), 407–417. https://doi.org/10.1016/j.cmet.2014.02.006
Li, Y., Pan, A., Wang, D. D., Liu, X., Dhana, K., Franco, O. H., … Hu, F. B. (2018). Impact of healthy lifestyle factors on life expectancies in the us population. Circulation, 138(4), 345–355. https://doi.org/10.1161/CIRCULATIONAHA.117.032047
Llewellyn, D. J., Langa, K. M., & Lang, I. A. (2009). Serum 25-hydroxyvitamin D concentration and cognitive impairment. Journal of Geriatric Psychiatry and Neurology, 22(3), 188–195. https://doi.org/10.1177/0891988708327888
Longo, V. D., & Mattson, M. P. (2014). Fasting: Molecular Mechanisms and Clinical Applications. Cell Metabolism, 19(2), 181–192. https://doi.org/10.1016/J.CMET.2013.12.008
Loomans-Kropp, H. A., Pinsky, P., Cao, Y., Chan, A. T., & Umar, A. (2019). Association of Aspirin Use With Mortality Risk Among Older Adult Participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. JAMA Network Open, 2(12), e1916729. https://doi.org/10.1001/jamanetworkopen.2019.16729
Luke, A., & Cooper, R. S. (2013). Physical activity does not influence obesity risk: time to clarify the public health message. International Journal of Epidemiology, 42(6), 1831–1836. https://doi.org/10.1093/ije/dyt159
Lustig, R. H., Schmidt, L. A., & Brindis, C. D. (2012, February 2). Public health: The toxic truth about sugar. Nature. https://doi.org/10.1038/482027a
Lustig, R. H., Francisco, S., Gugliucci, A., & Dean, A. (n.d.). Metabolic Syndrome Signaling.
Majid, M. F. (2015). The persistent effects of in utero nutrition shocks over the life cycle: Evidence from Ramadan fasting. Journal of Development Economics, 117, 48–57. https://doi.org/10.1016/j.jdeveco.2015.06.006
Mardinoglu, A., Wu, H., Bjornson, E., Zhang, C., Hakkarainen, A., Räsänen, S. M., … Borén, J. (2018). An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. Cell Metabolism, 27(3), 559-571.e5. https://doi.org/10.1016/j.cmet.2018.01.005
Marengo, A., Rosso, C., & Bugianesi, E. (2016). Liver cancer: connections with obesity, fatty liver, and cirrhosis. Annu. Rev. Med., 67, 103–117.
Mattson, M. P., Longo, V. D., & Harvie, M. (2017). Impact of intermittent fasting on health and disease processes. Ageing Research Reviews, 39, 46–58. https://doi.org/10.1016/J.ARR.2016.10.005
Mayo Clinic. (n.d.). Calcium and calcium supplements: Achieving the right balance - Mayo Clinic. Retrieved October 1, 2019, from https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/calcium-supplements/art-20047097
Mcgrath, M. (n.d.). J.I. Rodale: A Paranoid Publisher Who Became the Godfather of Organics | The New Republic. Retrieved March 23, 2020, from https://newrepublic.com/article/119007/bizarre-life-and-death-mr-organic
McCarron, D. A., Kazaks, A., Geerling, J. C., Sterns, J. S., & Graudal Niels, A. (2013). Normal Range of Dietary Sodium Intake. American Journal of Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/23978452
Mishra, S., & Palanivelu, K. (2008). The effect of curcumin (turmeric) on Alzheimer’s disease: An overview. Annals of Indian Academy of Neurology, 11(1), 13–19. https://doi.org/10.4103/0972-2327.40220
Moore, S. C., Lee, I. M., Weiderpass, E., Campbell, P. T., Sampson, J. N., Kitahara, C. M., … Patel, A. V. (2016). Association of leisure-time physical activity with risk of 26 types of cancer in 1.44 million adults. JAMA Internal Medicine, 176(6), 816–825. https://doi.org/10.1001/jamainternmed.2016.1548
Morgan, W. G. S. (1987). Exercise and Mental Health - Google Books. Retrieved from https://books.google.com/books?hl=en&lr=&id=Hhe1-tgUBNwC&oi=fnd&pg=PR11&dq=exercise+and+mental+health&ots=BEn-a05Q12&sig=QECRm87gzQ4-EKbVRMU1HC_d0v0#v=onepage&q=exercise and mental health&f=false
Moumtaz, S., Percival, B. C., Parmar, D., Grootveld, K. L., Jansson, P., & Grootveld, M. (2019). Toxic aldehyde generation in and food uptake from culinary oils during frying practices: peroxidative resistance of a monounsaturate-rich algae oil. Scientific Reports, 9(1), 4125. https://doi.org/10.1038/s41598-019-39767-1
Munro, H. M. (1978). Nutritional consequences of excess amino acid intake. Advances in Experimental Medicine and Biology, 105, 119–129. https://doi.org/10.1007/978-1-4684-3366-1_8
Narang’, R. L., Gupta’, K. R., Narang, A. P. S., & Singh"’, R. (1991). LEVELS OF COPPER AND ZINC IN DEPRESSION. Indian J Physiol Pharmacol (Vol. 3). Retrieved from http://www.ijpp.com/IJPP archives/1991_35_4/272-274.pdf
National Institute on Alcohol Abuse and Alcoholism (U.S.), K. J., States. Alcohol, D. A., & National Institutes of Health (U.S.). (2001)., United Alcohol health and research world. Alcohol Research (Vol. 25). U.S. Government Printing Office. Retrieved from https://www.questia.com/library/journal/1P3-88707977/alcohol-s-effects-on-sleep-in-alcoholics
NH Health. (2014). How much sugar do you eat? Retrieved September 8, 2019, from https://www.dhhs.nh.gov/dphs/nhp/documents/sugar.pdf
NIH. (n.d.-a). Folate — Health Professional Fact Sheet. Retrieved October 19, 2019, from https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/
NIH. (n.d.-b). Omega-3 Fatty Acids — Consumer. Retrieved from https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/
NIH. (n.d.-c). Vitamin C — Health Professional Fact Sheet. Retrieved October 6, 2019, from https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/
NIH. (n.d.-d). Vitamin D — Health Professional Fact Sheet. Retrieved September 30, 2019, from https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
Nyberg, S. T., Singh-Manoux, A., Pentti, J., Madsen, I. E. H., Sabia, S., Alfredsson, L., … Kivimäki, M. (2020). Association of Healthy Lifestyle with Years Lived without Major Chronic Diseases. JAMA Internal Medicine, 180(5), 1. https://doi.org/10.1001/jamainternmed.2020.0618
O’Donnell, M., Mente, A., Rangarajan, S., McQueen, M. J., Wang, X., Liu, L., … Yusuf, S. (2014). Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events. New England Journal of Medicine, 371(7), 612–623. https://doi.org/10.1056/NEJMoa1311889
Ohnuma, T., Toda, A., Kimoto, A., Takebayashi, Y., Higashiyama, R., Tagata, Y., … Arai, H. (2016). Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer’s disease: a prospective, open-label pilot study. Clinical Interventions in Aging, 11, 29. https://doi.org/10.2147/CIA.S95362
Ota, M., Matsuo, J., Ishida, I., Takano, H., Yokoi, Y., Hori, H., … Kunugi, H. (2019). Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease. Neuroscience Letters, 690, 232–236. https://doi.org/10.1016/j.neulet.2018.10.048
Otto, M. W., Church, T. S., Craft, L. L., Greer, T. L., Smits, J. A. J., Trivedi, M. H., & Trivedi, M. H. (2007). Exercise for mood and anxiety disorders. Primary Care Companion to the Journal of Clinical Psychiatry, 9(4), 287–294. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17934553
Owen, O. E., Morgan, A. P., Kemp, H. G., Sullivan, J. M., Herrera, M. G., & Cahill, G. F. (1967). Brain metabolism during fasting. The Journal of Clinical Investigation, 46(10), 1589–1595. https://doi.org/10.1172/JCI105650
Page, K. A., Chan, O., Arora, J., Belfort-DeAguiar, R., Dzuira, J., Roehmholdt, B., … Sherwin, R. S. (2013). Effects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways. JAMA, 309(1), 63. https://doi.org/10.1001/jama.2012.116975
Parry, B. L., & Maurer, E. L. (2003). Light treatment of mood disorders. Dialogues in Clinical Neuroscience, 5(4), 353–365. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22033495
Persad, L. A. B. (2011). Energy drinks and the neurophysiological impact of caffeine. Frontiers in Neuroscience, 5, 116. https://doi.org/10.3389/fnins.2011.00116
Pierotti, T., Fortier, M., … Castellano, C.-A. (2016). Can ketones compensate Cunnane, S. C., Courchesne-Loyer, A., St-Pierre, V., Vandenberghe, C., for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease. Annals of the New York Academy of Sciences, 1367(1), 12–20. https://doi.org/10.1111/nyas.12999
Pharmacology. (n.d.). Growth Promotion — Antimicrobial Resistance Learning Site For Veterinary Students. Retrieved September 11, 2019, from https://amrls.cvm.msu.edu/pharmacology/antimicrobial-usage-in-animals/non-therapuetic-use-of-antimicrobials-in-animals/use-of-antibiotics-in-animals-for-growth-promotion
Understanding nutrition, depression and mental illnesses Rao, T. S. Sathyanarayana; Asha, M. R.1; Ramesh, B. N.2; Rao, K. S. Jagannatha2 https://journals.lww.com/indianjpsychiatry/Fulltext/2008/50020/Understanding_nutrition,_depression_and_mental.1.aspx
Rao TS1, Asha MR, Ramesh BN, R. K. (2008). Understanding nutrition, depression and mental illnesses. Indian journal of psychiatry (Vol. 50). Wolters Kluwer -- Medknow Publications. https://doi.org/10.4103/0019-5545.42391
Rasch B1, B. J. (2013). About sleep’s role in memory. Physiological reviews (Vol. 93). American Physiological Society. https://doi.org/10.1152/physrev.00032.2012
Ravnskov, U., de Lorgeril, M., Diamond, D. M., Hama, R., Hamazaki, T., Hammarskjöld, B., … Sundberg, R. (2018). LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature. Expert Review of Clinical Pharmacology, 11(10), 959–970. https://doi.org/10.1080/17512433.2018.1519391
Rimm, E. B., Klatsky, A., Grobbee, D., & Stampfer, M. J. (n.d.). PAPERS Review ofmoderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits? Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350477/pdf/bmj00534-0017.pdf
Rosanoff, A., Weaver, C. M., & Rude, R. K. (2012). Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutrition Reviews, 70(3), 153–164. https://doi.org/10.1111/j.1753-4887.2011.00465.x
Rosch, P. (n.d.). Fat and cholesterol don’t cause heart attacks and statins are not the solution. https://www.amazon.com/Cholesterol-Cause-Attacks-Statins-Solution/dp/190779753X
Rubin, R. (2019, February 4). Backlash over Meat Dietary Recommendations Raises Questions about Corporate Ties to Nutrition Scientists. JAMA - Journal of the American Medical Association. American Medical Association. https://doi.org/10.1001/jama.2019.21441
Sakuyama, H., Katoh, M., Wakabayashi, H., Zulli, A., Kruzliak, P., & Uehara, Y. (2016). Influence of gestational salt restriction in fetal growth and in development of diseases in adulthood. Journal of Biomedical Science, 23(1), 12. https://doi.org/10.1186/s12929-016-0233-8
Sateia, M. J. (2014). International Classification of Sleep Disorders-Third Edition. Chest, 146(5), 1387–1394. https://doi.org/10.1378/chest.14-0970
Savage, R. D., Visentin, J. D., Bronskill, S. E., Wang, X., Gruneir, A., Giannakeas, V., … McCarthy, L. M. (2020). Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults With Hypertension. JAMA Internal Medicine. https://doi.org/10.1001/jamainternmed.2019.7087
Sawicki, C. M., Livingston, K. A., Obin, M., Roberts, S. B., Chung, M., & McKeown, N. M. (2017). Dietary Fiber and the Human Gut Microbiota: Application of Evidence Mapping Methodology. Nutrients, 9(2), 125. https://doi.org/10.3390/nu9020125
Seidelmann, S. B., Claggett, B., Cheng, S., Henglin, M., Shah, A., Steffen, L. M., … Solomon, S. D. (2018). Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. The Lancet Public Health, 3(9), e419–e428. https://doi.org/10.1016/S2468-2667(18)30135-X
Seneff, S., Wainwright, G., & Mascitelli, L. (2011, April 1). Nutrition and Alzheimer’s disease: The detrimental role of a high carbohydrate diet. European Journal of Internal Medicine. Elsevier B.V. https://doi.org/10.1016/j.ejim.2010.12.017
Shilhavy, B. (2019). Time Magazine: We Were Wrong About Saturated Fats. Retrieved September 6, 2019, from https://healthimpactnews.com/2014/time-magazine-we-were-wrong-about-saturated-fats/
Seidelmann, S. B., Claggett, B., Cheng, S., Henglin, M., Shah, A., Steffen, L. M., … Solomon, S. D. (2018). Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. The Lancet Public Health, 3(9), e419–e428. https://doi.org/10.1016/S2468-2667(18)30135-X
Simopoulos, A. P. (2016). An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity. Nutrients, 8(3), 128. https://doi.org/10.3390/nu8030128
Song, H., Sieurin, J., Wirdefeldt, K., Pedersen, N. L., Almqvist, C., Larsson, H., … Fang, F. (2020). Association of Stress-Related Disorders with Subsequent Neurodegenerative Diseases. JAMA Neurology, E1–E10. https://doi.org/10.1001/jamaneurol.2020.0117
Spillane, S., Shiels, M. S., Best, A. F., Haozous, E. A., Withrow, D. R., Chen, Y., … Freedman, N. D. (2020). Trends in Alcohol-Induced Deaths in the United States, 2000-2016. JAMA Network Open, 3(2), e1921451. https://doi.org/10.1001/jamanetworkopen.2019.21451
Stanhope, K. L., Schwarz, J. M., Keim, N. L., Griffen, S. C., Bremer, A. A., Graham, J. L., … Havel, P. J. (2009). Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. The Journal of Clinical Investigation, 119(5), 1322–1334. https://doi.org/10.1172/JCI37385
Staff, M. C. (n.d.). Alzheimer’s disease - Diagnosis and treatment - Mayo Clinic. Retrieved April 2, 2020, from https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/diagnosis-treatment/drc-20350453
Stekovic, S., Hofer, S. J., Tripolt, N., Aon, M. A., Royer, P., Pein, L., … Madeo, F. (2019). Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans. Cell Metabolism, 30(3), 462-476.e5. https://doi.org/10.1016/j.cmet.2019.07.016
Sullivan, Mark Simon, Greg Spertus, John Russo, J. (n.d.). Depression-Related Costs in Heart Failure Care | https://www.ncbi.nlm.nih.gov/pubmed/12196084
Talbot, K., Wang, H. Y., Kazi, H., Han, L. Y., Bakshi, K. P., Stucky, A., … Arnold, S. E. (2012). Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. Journal of Clinical Investigation, 122(4), 1316–1338. https://doi.org/10.1172/JCI59903
Tappy, L., & Le, K. A. (2010). Metabolic effects of fructose and the worldwide increase in obesity. Physiological Reviews. https://doi.org/10.1152/physrev.00019.2009
Taylor, M. K., Sullivan, D. K., Mahnken, J. D., Burns, J. M., & Swerdlow, R. H. (2018). Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer’s disease. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 4(1), 28–36. https://doi.org/10.1016/j.trci.2017.11.002
USDA. (2016). USDA National Nutrient Database. Retrieved from https://ods.od.nih.gov/pubs/usdandb/DHA-Content.pdf
Verrijken, A., Francque, S., & Gaal, L. Van. (2010). The Role of Visceral Adipose Tissue in the Pathogenesis of Non-alcoholic Fatty Liver Disease. European Endocrinology, 7(2), 96. https://doi.org/10.17925/EE.2011.07.02.96
Vos, M. B., & Lavine, J. E. (2013). Dietary fructose in nonalcoholic fatty liver disease. Hepatology, 57(6), 2525–2531. https://doi.org/10.1002/hep.26299
Voulgari, C., Tentolouris, N., Dilaveris, P., Tousoulis, D., Katsilambros, N., & Stefanadis, C. (2011). Increased Heart Failure Risk in Normal-Weight People With Metabolic Syndrome Compared With Metabolically Healthy Obese Individuals. Journal of the American College of Cardiology, 58(13), 1343–1350. https://doi.org/10.1016/J.JACC.2011.04.047
Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., … Heald, J. L. (2015). Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion. Journal of Clinical Sleep Medicine, 11(08), 931–952. https://doi.org/10.5664/jcsm.4950
WHO. (n.d.). WHO | 2. Background. Retrieved March 21, 2020, from https://www.who.int/nutrition/topics/2_background/en/
Winchester. (n.d.). Contractures | Winchester Hospital. Retrieved March 22, 2020, from https://www.winchesterhospital.org/health-library/article?id=11932
Wolfe, R. R. (2012). The role of dietary protein in optimizing muscle mass, function and health outcomes in older individuals. British Journal of Nutrition, 108(SUPPL. 2). https://doi.org/10.1017/S0007114512002590
Woodman. (n.d.). Appendix 3: Starch Content of Vegetables and Fruits. Retrieved March 21, 2020, from http://woodmed.com/index.php/health-information/basic-health-maintenance-diet/135-appendix-3-starch-content-of-vegetables-and-fruits
Yang, J., Christophi, C. A., Farioli, A., Baur, D. M., Moffatt, S., Zollinger, T. W., & Kales, S. N. (2019). Association Between Push-up Exercise Capacity and Future Cardiovascular Events Among Active Adult Men. JAMA Network Open, 2(2), e188341. https://doi.org/10.1001/jamanetworkopen.2018.8341
Yang, I. H., Enrique De La, J., Ortí, R., Sabater, P. S., Castillo, S. S., Rochina, M. J., … Montoya-Castilla, I. (2015). Aceite de coco: tratamiento alternativo no farmacológico frente a la enfermedad de Alzheimer. Nutr Hosp, 32(6), 2822–2827. https://doi.org/10.3305/nh.2015.32.6.9707
Yin, J. X., Maalouf, M., Han, P., Zhao, M., Gao, M., Dharshaun, T., … Shi, J. (2016). Ketones block amyloid entry and improve cognition in an Alzheimer’s model. Neurobiology of Aging, 39. https://doi.org/10.1016/j.neurobiolaging.2015.11.018
Zarate, R., El Jaber-Vazdekis, N., Tejera, N., Pérez, J. A., & Rodríguez, C. (2017). Significance of long chain polyunsaturated fatty acids in human health. Clinical and Translational Medicine, 6(1), 25. https://doi.org/10.1186/s40169-017-0153-6
Zhao, J. G., Zeng, X. T., Wang, J., & Liu, L. (2017, December 26). Association between calcium or Vitamin D supplementation and fracture incidence in community-dwelling older adults a systematic review and meta-analysis. JAMA - Journal of the American Medical Association. American Medical Association. https://doi.org/10.1001/jama.2017.19344
Understanding Alzheimer's Disease
Robert Harrison Black
Alzheimer's disease (AD) is named after Dr. Alois Alzheimer. In 1906, Dr. Alzheimer documented changes in the brain tissue of a woman who had died at age 55 of a rare mental illness.
In AD, as neurons are injured and die throughout the brain, connections between networks of neurons may break down, and many brain regions begin to shrink. By the final stages of AD, this process—called brain atrophy—is widespread, causing significant brain volume loss. (NIH, no date)
AD has been studied with microscopes and other scientific equipment. I looked at AD from a global perspective. AD was rare and is now common and becoming a pandemic. As a good scientist, I ask what has changed.
Our genetics have not changed.
We are getting older, which would explain part of the increase.
We are sitting more watching TV or on a computer.
Smoking has declined. I could not find a biochemical link that would increase AD by reducing smoking.
We are consuming a great deal of added sugars. These added sugars include fructose. (Seneff et al., 2010)
We have decreased our consumption of sodium chloride (salt)
We are consuming more inflammatory omega-6 oils.
Life Style Studies:
Livingston, writing in Lancet, said less education, hypertension, hearing impairment, smoking, obesity, depression, physical inactivity, diabetes, low social contact, excessive alcohol consumption, traumatic brain injury, and air pollution account for around 40% of worldwide dementias. These dementias could theoretically be prevented or delayed. The potential for prevention is high and might be higher in low-income and middle-income countries where more dementias occur. (Livingston et al., 2020)
The items on Livingston's list match recommendations for a healthy heart and a lower risk of cancer. These recommendations and those from Baumgart (below) will increase the likelihood of a better life; everyone should follow these recommendations. However, these recommendations show how to reduce the risk of AD but do not show how to reverse AD progression.
Melzer et al. stress the need for micronutrients such as vitamins and minerals to maintain health. They also recommend optimizing macronutrients. This recommendation was not further developed. They assert nutritional status as the most critical modifiable factor regulating the gut microbiota at different time points across the lifespan and under various health conditions. The brain-gut link is identified as essential. (Melzer, Manosso, Yau, Gil-Mohapel, & Brocardo, 2021)
Chart 1 Cognitive decline risk factors for AD
This chart by Baumgart (above) outlines how to avoid AD and other dementias. I have reviewed many clinical studies that describe the Mediterranean diet. They are not consistent, but they have two things in common. They are low in added sugars, and use olive oil and not inflammatory vegetable oils like soybean oil. (Baumgart et al., 2015) Appendix A explains why the term Mediterranean Diet is not useful. Appendix B provides a clear description of a diet to combat AD.
Both gingivitis and E. coli bacteria have been implicated in AD. When I first read the gingivitis study, I thought: Of course, AD patients forget to brush their teeth. Both of these bacteria live on dead tissue. The dead brain cells provide nourishment for these bacteria. (Anderson, 2021) (Zhan et al., 2016) Zahn has noted the fibers in E. coli and their similarity to those in AD. These bacteria may be more a symptom than a cause. In both studies, healthy brains had some gingivitis and E. coli bacteria.
Sugar consumption:
AD increase correlates with the increased intake of added sugars; these include sucrose, high fructose corn syrup, maple syrup, agave, honey, and others. The average American ate only 2 pounds of added sugar a year two hundred years ago. (NH Health, 2014)
Year Consumption
1814 - 2 pounds per year
1970 - 123 pounds per year
2014 - 152 pounds per year
Table 1 Added sugar consumption per year
In one year, we now consume about 152 pounds of added sugar or nearly 3 pounds per week.
Increased sugar consumption is linked to AD. Both correlation and biochemistry show this link.
There is an agreement in the literature that brain glucose uptake is impaired in AD. Can cognitive decline be delayed if this brain energy defect is partly corrected or bypassed early in the disease? The principal ketones (also called ketone bodies), β-hydroxybutyrate and acetoacetate, are the brain's primary physiological alternative fuel to glucose. These two of many studies in mild-to-moderate AD have shown that these brain ketones are as useful to the brain as glucose in healthy age-matched controls. (Cunnane et al., 2016) (Juby 2022) Published clinical trials demonstrate that increasing ketone availability to the brain via moderate nutritional ketosis with medium-chain triglyceride oil has a beneficial effect on cognitive outcomes in mild-to-moderate AD and mild cognitive impairment. (Juby 2022)
Dietary Fats:
We are also consuming omega 6 seed oils. These oils cause inflammation that damages all tissue, including the heart, brain, kidneys, and pituitary.
Oil Type 1814 1909 1999 Percent increase
Soybean 0 0.01 11.6 116,300
Canola1 0 0.01 0.8 16,700
Safflower3 0 0.04 0.05 25
Cottonseed 0 0.4 0.31 −21
Table 2 Consumption of omega-6 oils in Kilograms per person per year
Omega 6 oil consumption has also tracked AD. Something changes in the brain from being able to use glucose for fuel to needing β-hydroxybutyrate and acetoacetate. The cause of this change in brain metabolism has not been found. Double-blind and biochemical studies are required to know what these oils do to us.
In addition omega-6 fats are unsaturated and more likely to become oxidized in LDL cholesterol. These oxidized LDL particles cannot be used in cells and will continue circulating, causing systemic inflammation. Oxidized LDL will also stick to the walls of the arteries causing plaques. Fats sticking to the walls of arteries causes a cascade of events that lead to clots. This cascade consists of continued accumulation of fatty deposits, attempts by white blood cells to clear the oxidized LDL from the arterial walls, inflammation signals from the white cells, inflammation of the blood vessels that have the deposits, and finally, the buildup of deposits and the formation of clots. Ravnskov and Kromer focused on heart disease, but the findings may also apply to the even finer capillaries in the brain. (Ravnskov et al., 2014) (Kromer, 2018)
Omega 3 fatty acids, primarily from fish, have been shown to reduce the probability of AD (Ma, 2020). Olive oil is low in omega-6 fatty acids, which may be why some Mediterranean diets show positive results.
Studies:
Kane et al. have done a compensative study of attempts to cure AD. Some of the studies provided temporary symptom relief, but none prevented the progress of the disease. "We found mostly low-strength evidence that a wide variety of interventions had little to no benefit for preventing or delaying age-related cognitive decline." (Kane, M.D., Butler, Ph.D., MBA, & Fink, M.D., MPH, 2017) Ketogenic and medium-chain triglyceride diet was not on the list of treatments studied by Kane et al..
A high-fat ketogenic diet can achieve nutritional ketosis by providing 20–70 g/day of medium-chain triglycerides containing the eight- and ten-carbon fatty acids octanoate and decanoate or by ketone esters. (de la Rubia et al., 2020) Insulin blocks the metabolism of fats and promotes the storage of body fat. To use eight- and ten-carbon fatty acids, octanoate, and decanoate, carbohydrates must be limited. Given the acute dependence of the brain on its energy supply, it seems reasonable that the development of therapeutic strategies aimed at AD must target how the underlying problem of deteriorating brain fuel supply can be corrected or delayed.
There are many patients on a ketogenic diet to prevent seizures. The ketogenic diet is high in fat, adequate in protein, and very low in carbohydrates. A typical ketogenic diet for controlling seizures consists of 70% to 80% fats, 20% proteins, and 5% to 10% carbohydrates. Doctors typically recommend the keto diet to treat epilepsy in children of all ages, including infants. Ketogenic diets usually are not preferred by adults because the limited food choices make the diet hard to maintain. The keto diet has also been used in other neurological conditions, including AD and an autism spectrum disorder. (Caraballo, n.d.)
Taylor et al. found that AD could be reversed using medium-chain triglycerides and a ketogenic diet. Their trial only succeeded with subjects with very mild or mild cognitive impairment. With the more severely cognitively impaired, the dropout rate was 100%. These studies have a problem with the subject's unwillingness to stay on the diet or the heavy caregiver burden being too hard. (Taylor, Sullivan, Mahnken, Burns, & Swerdlow, 2018)
Melzer et al. recognized the loss of the ability of the brain to use glucose and the effectiveness of medium-chain triglycerides in the pathology of AD. This revelation was not further developed. (Melzer, Manosso, Yau, Gil-Mohapel, & Brocardo, 2021)
Coconut oil is high in medium-chain fatty acids, easily converted to beta-hydroxybutyrate and acetoacetate; our brain can use these in place of glucose. Many studies have been done on both coconut oil and medium-chain triglyceride oil. I reference one by W M A D B Fernando. (Fernando, 2015) All of the studies with medium-chain triglyceride oil show positive results. Most studies with coconut oil studies show positive results.
The study by Xu et al. showed a significant (p < 0.01) reduction in the AD assessment scale scores used by Xu. There was a 2.62 improvement for the medium-chain triglyceride oil. And a 2.57 reduction in the score for the placebo over 30 days. They used medium-chain triglycerides (MCT) oil with canola oil as a control. The TC, HDL-C, β-hydroxybutyrate, and acetoacetate concentrations were significantly higher in the MCT group than in the placebo group. (Xu et al., 2020)
Roy et al. used multimodal imaging to show that a ketogenic intervention in mild cognitive impairment improved the functional, metabolic and structural integrity of the dorsal attention network. This network enables us to interact with the environment. The 6-month ketogenic medium chain triglyceride supplementation increased functional connectivity within the dorsal attention network as a direct function of improved brain energy status due to higher brain ketone availability. Attention also improved as a function of enhanced functional connectivity. Analysis of the comprehensive structural map of neural connections in the brain revealed increased fiber density within the dorsal attention network following ketogenic medium-chain triglyceride consumption. (Roy et al., 2022)
Rebello et al. "Consumption of 56 g/day of medium chain triglycerides for 24 weeks increases serum ketone concentrations and appears to be a candidate for larger randomized control trials in the future that quantify the modulation of cognitive function through supplementation with ketone precursors in patients with mild cognitive mild impairment." (Rebello et al., 2015)
Mental exercises have a minimal long-term effect in preventing a decline in cognitive function. The researchers found that mental stimulation improved memory and thinking test scores for those with dementia, equivalent to about a six to nine-month delay in worsening symptoms. Some studies found dementia patients who engaged in such activities had increased feelings of well-being and a better quality of life, including improved communication and interactions with those around them. They were, however, no better able to care for themselves or function independently. (Woods, Aguirre, Spector, & Orrell, 2012)
Changes from baseline scores for exercise program patients showed a slower decline than in patients receiving routine medical care. No effect was observed for behavioral disturbance, depression, or nutritional assessment scores. (Rolland et al., 2007)
Drugs for AD:
Drugs have not been shown to reverse AD. The recently approved drug Aducanumab is one in a long line of failed drugs that prevent or reduce amyloid beta plaques. Aducanumab was approved over the objection of the scientific review panel. Trials of Aducanumab have shown mixed results. It will likely fail because the prevention of amyloid beta has consistently failed to delay or reverse AD. Other drugs stimulate the brain and provide the temporary appearance of delay or reversal. None have been shown to delay or reverse AD permanently.
Tampi, Forester, & Agronin also reviewed the clinical trials of Aducanumab. They did not find evidence of a long-term benefit from Aducanumab. They showed why the Drugs Advisory Committee of the FDA voted, with ten members against it and one member uncertain that it was not reasonable to consider the evidence of clinical benefit from Study 302 as primary evidence of the effectiveness of aducanumab. (Tampi, Forester, & Agronin, 2021)
Until recently, in the United States, only five treatments were approved by the US FDA for neurocognitive symptoms of AD. These include three cholinesterase inhibitors (donepezil, galantamine, and rivastigmine), one N-methyl-D-aspartate receptor antagonist (memantine), and a combination of donepezil and rivastigmine. The first four drugs are also licensed in the European Union. In the United States, a fixed-dose combination of donepezil and memantine was approved in 2014 for treating individuals with moderate to severe AD dementia who are stable on donepezil. These drugs reduce symptoms but do not slow the progression of AD. (Tampi, Forester, & Agronin, 2021)
Mehta et al. studied the failure of AD drugs. The article was titled "Why do trials for AD drugs keep failing?" They reviewed drugs that were anti-amyloid monoclonal antibodies, used gamma-secretase to decrease the production of amyloid, controlled tau protein, enhanced neurochemicals, and blocked antihistamines. All were failures. (Mehta, O'Donnell, and Yusuf, 2021)
The Indian spice curcumin is a principal constituent of the spice turmeric. Recent research on amyloid-β and curcumin has revealed that curcumin prevents amyloid-β aggregation and crosses the blood-brain barrier (BBB), reaches brain cells, and protects neurons from various toxic insults of aging and amyloid-β in humans." (Reddy et al., 2018) Molecular variations of curcumin may also be effective against AD.
Salt:
"There is evidence that high salt intake is associated with poor cognition. However, findings are mixed due to poor methodological quality and the studies' heterogeneous dietary, analytical, and cognitive assessment methods and design. Reduced sodium intake may be a potential target for intervention. High-quality prospective studies and clinical trials are needed." (Mohan et al., 2020)
O'Donnell found that a salt intake between 3 and 6 grams per day was associated with a lower risk of death. This quantity is what we naturally consume. The lowest level of AD was when consuming salt to taste. This level of salt intake is between 3 to 5 grams per day. Low salt may be part of the problem; I did not find any double-blind clinical studies on salt and AD. (O’ Donnell et al. 2014)
Discussion:
Correlation is not causation; we must have good clinical studies and biochemical mechanisms.
Genetics have been studied concerning AD. Some genetics have been linked to an increased risk of AD, but no studies show a new gene is spreading in the adult population.
An aging population has more time for AD symptoms to become apparent. We are getting older, which would explain at least part of the increase. Also, more people are being diagnosed earlier.
Our increasingly sedentary lifestyle is likely a cause of a portion of the increase. Intellectual stimulation has been shown to slow the development of AD. By delaying the diagnosis, some people who would have been diagnosed with AD may die of other causes before diagnosis.
I did not find a link to smoking cessation.
This linkage is also true of Omega 6 oils. Both correlation and biochemistry show this link. We do not have a way to determine the percentage is caused by sugar and what percentage is Omega 6 oils.
Eliminating carbohydrate consumption to obtain at least partial ketosis and providing medium-chain triglycerides successfully stopped the progression and partially reversed cognitive decline. (De la Rubia Ortí JE, 2020) Age Successfully Second Edition provides a diet that meets the requirements of De la Rubia Ortí JE to prevent and reverse cognitive decline (Black, 2020). This diet prevents further neuron death. New brain cells are added slowly to the brain in older subjects. The brain is plastic, and some recovery can be made by brain reorganization. To live a normal life, including personal hygiene, the diet must be started before significant neuron death has occurred.
Conclusion:
Diet is the only treatment shown to work in the long run. (De la Rubia Ortí JE, 2020) Age Successfully Second Edition, pages 135-136, provides the diet that meets the requirements of De la Rubia Ortí JE to prevent and reverse cognitive decline. An updated and improved version of this diet is in appendix B. (Black, 2020).
Appendix:
A) The Mediterranean diet MD
MD is recommended in many studies, used against control in clinical studies, and is recommended in most health literature. Often it is not defined, and the reader is left to determine what it is. Is the MD lots of pasta and red wine? When the MD is defined, it is usually a diet high in fruits and vegetables with whole grain cereals, olive oil, and fish. There are many flaws in this diet description. I have been to Italy, eaten in their restaurants, visited their grocery stores, and observed what the people eat. Italian pasta and Italian bread are not whole grains. Cereals on the shelves in the United States, even when they claim to contain whole grain, typically have little whole grain and large quantities of added sugars.
Fruits and vegetables are not the same. Most vegetables have evolved to contain toxins against microbes and animals who would eat them (D, D, A, & I V, 2016). Recommending green leafy vegetables is not specific enough. For example, spinach contains oxalic acid, and if it were a large part of a diet, oxalic acid would block iron absorption, thereby causing anemia. Fruits typically have toxins when the seeds have not been developed enough to pass through the vector unharmed. Fruit seeds usually contain toxins to prevent them from being eaten (Medical News). Fruits are high in sugar, with fructose being the most concerning.
Some fructose from sugar will gain access to the brain, increasing appetite and blocking the signal that tells the brain to stop eating. Fructose can not be used by cells for energy. It must be converted to fat by the liver. Some of this fat is stored by the liver, causing fatty liver disease; some is released into the bloodstream as small particle triglycerides; These particles can cause arterial blockages.
We need to stop using the term Mediterranean diet and be specific when recommending a diet.
B) A diet for AD based on the AD diet in Age Successfully and additional research:
The Cunnane and the Seneff papers explain the principles of changing the brain from glucose fuel to ketone fuel to combat AD and other health problems. We need to provide medium-chain fatty acids that can be converted to ketones and reduce glucose availability to force the conversion. The conversion happens when in or partially in ketosis. This treatment is based on the theory that the brain loses its ability to use glucose and does not lose its ability to use ketones for energy. The brain can grow more cells and synapses, but this is slow. This treatment must be started early before a significant part of the brain is lost. If Cunnane is right, amyloid and tau proteins can be thought of as brain scar tissue and not the cause of the problem. This diet will provide the ketones without being in full ketosis.
Stopping the loss of intellectual capacity is not easy and requires the person progressing to or with AD to put in the effort. Any attempt to cure AD will only work if the subject has a reason to be intellectually active. This need for motivation is particularly important for the spouse or caregiver. There needs to be a life purpose or life goals. If the subject is simply in a retirement facility waiting to die, they have no incentive to improve their intellectual capacity. Without a life purpose, why not have AD? In later stages, it is less stressful.
An effective AD cure requires diabetes to be cured first. The presence of significant insulin will prevent ketone metabolism.
After the diabetes is cured, start the first step to eliminate AD: take two tablespoons of Medium Chain Triglyceride (MCT) oil three times a day. (de la Rubia et al., 2020) MCT oil can have a laxative effect and can cause digestive upset. It may need to be added incrementally.
Use coconut oil for cooking at low temperatures and virgin olive oil for higher temperatures. Eliminating omega-6 fatty acids will reduce inflammation.
Eat two eggs a day to increase protein and cholesterol availability. Our brain can be considered a bag of cholesterol with an embedded electronic quantum computer.
Eliminate added sugars to reduce A1c.
Take 2 grams of turmeric (curcumin) daily to clear amyloid plaque proteins from the brain. (Reddy et al., 2018)
Eat sufficient animal protein. For persons over 60, this can be daunting. Baum et al. recommend between 1.2 and 2 grams per day for the elderly. I weigh 175 pounds (79kg) and am 83 years old. I ride my bike and work out in the gym daily. Based on that, I should consume 85 grams of protein per day. An egg has 14 grams of protein. Four oz of raw ground beef has 21 grams of protein. (Baum, 2016)
Take an omega-3 oil supplement that has DHA.
Maintaining an adequate fiber intake and carbohydrate reduction to less than 10% will require replacing potatoes, sweet potatoes, rice, corn, bread, carrots, beets, and other starchy foods with high-fiber vegetables.
Physical exercise and mental exercise are needed to keep the brain active. Both physical and mental activity encourages new brain cell formation and synapse formation.
Use intermittent fasting to clear inactive proteins and mitochondria.
Authors note: I use a modified version of this diet every day. I consume more carbohydrates than the diet above and fast 18 hours daily from 6:00 pm until Noon the next day. My brain is still intact.
References:
Anderson, P. (n.d.). Gum Disease Bacteria a New Treatment Target for AD? Retrieved October 2, 2022, from https://www.medscape.com/viewarticle/963574?uac=362670CN&faf=1&sso=true&impID=3824361&src=wnl_edit_tpal#vp_2
Baum, J. I., Kim, I. Y., & Wolfe, R. R. (2016, June 8). Protein consumption and the elderly: What is the optimal level of intake? Nutrients. MDPI AG. https://doi.org/10.3390/nu8060359
Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015). Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective. AD & Dementia, 11(6), 718–726. https://doi.org/10.1016/J.JALZ.2015.05.016
Age Successfully Second Edition: Black, Robert Harrison: 9798646852916: Amazon.com: Pages 117-121 and 135-136 Books. (n.d.). Retrieved February 6, 2022, from https://www.amazon.com/Successfully-Second-Robert-Harrison-Black/dp/B088T5GJ8B
Caraballo, R. (n.d.). Ketogenic Diet For Epilepsy / Seizures. Retrieved October 14, 2022, from https://my.clevelandclinic.org/health/treatments/7156-ketogenic-diet-keto-diet-for-epilepsy
Chatterjee, S., Peters, S. A. E., Woodward, M., Arango, S. M., Batty, G. D., Beckett, N., … Huxley, R. R. (2016). Type 2diabetes as a risk factor for dementia in women compared with men: A pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia. Diabetes Care, 39(2), 300–307. https://doi.org/10.2337/dc15-1588
Cunnane, S. C., Courchesne-Loyer, A., Vandenberghe, C., St-Pierre, V., Fortier, M., Hennebelle, M., … Castellano, C. A. (2016). Can ketones help rescue brain fuel supply in later life? Implications for cognitive health during aging and the treatment of AD. Frontiers in Molecular Neuroscience, 9(JUL). https://doi.org/10.3389/fnmol.2016.00053
(D, D, A, & I V, 2016) https://www.researchgate.net/publication/301646957_A_SYSTEMATIC_REVIEW_OF_NATURAL_TOXINS_IN_FOOD_PLANTS
W M A D B Fernando et al The role of dietary coconut for the prevention and treatment of AD: potential mechanisms of action https://pubmed.ncbi.nlm.nih.gov/25997382/
Juby, Angela G corresponding authors, Toni E. Blackburn, and Diana R. Mager Use of medium chain triglyceride (MCT) oil in subjects with Alzheimer's disease: A randomized, double‐blind, placebo‐controlled, crossover study, with an open‐label extension https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919247/
Kane, M.D., R. L., Butler, Ph.D., M.B.A., M., & Fink, M.D., M.P.H., H. A. (2017). Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer's-Type Dementia. https://doi.org/10.23970/AHRQEPCCER188
Kroemer, G., López-Otín, C., Madeo, F., & de Cabo, R. (2018, October 18). Carbotoxicity—Noxious Effects of Carbohydrates. Cell. Cell Press. https://doi.org/10.1016/j.cell.2018.07.044
Lambrechts, D. A. J. E., Bovens, M. J. M., De la Parra, N. M., Hendriksen, J. G. M., Aldenkamp, A. P., & Majoie, M. J. M. (2013). Ketogenic diet effects on cognition, mood, and psychosocial adjustment in children. Acta Neurologica Scandinavica, 127(2), 103–108. https://doi.org/10.1111/J.1600-0404.2012.01686.X
Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., … Mukadam, N. (2020). Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet (London, England), 396(10248), 413. https://doi.org/10.1016/S0140-6736(20)30367-6
Ma, Qiu-Lan, et al. The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based AD Models https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596305/
Medical News Today Apple seed toxins https://www.medicalnewstoday.com/articles/318706#risks
Mehta D, Jackson R, Paul G, Shi J, Sabbagh M. Why do trials for AD drugs keep failing? A discontinued drug perspective for 2010-2015. Expert Opin Investig Drugs. 2017 Jun;26(6):735-739. doi: 10.1080/13543784.2017.1323868. PMID: 28460541; PMCID: PMC5576861.
Mente, A., O'Donnell, M., & Yusuf, S. (2021, June 1). Sodium and health: Another challenge to the current dogma. European Heart Journal. Oxford University Press. https://doi.org/10.1093/eurheartj/ehaa1093
Melzer, T. M., Manosso, L. M., Yau, S. Y., Gil-Mohapel, J., & Brocardo, P. S. (2021). In Pursuit of Healthy Aging: Effects of Nutrition on Brain Function. International Journal of Molecular Sciences, 22(9). https://doi.org/10.3390/IJMS22095026
Mohan, D., Yap, K. H., Reidpath, D., Soh, Y. C., McGrattan, A., Stephan, B. C. M., … Pase, M. (2020). Link Between Dietary Sodium Intake, Cognitive Function, and Dementia Risk in Middle-Aged and Older Adults: A Systematic Review. Journal of AD, 76(4), 1347. https://doi.org/10.3233/JAD-191339
NH Health. (2014). How much sugar do you eat? Retrieved September 8, 2019, from https://www.dhhs.nh.gov/dphs/nhp/documents/sugar.pdf
NIH. (n.d.). What Happens to the Brain in AD? | National Institute on Aging. Retrieved October 2, 2022, from https://www.nia.nih.gov/health/what-happens-brain-alzheimers-disease
(O'Donnell et al., 2014)Mente, A., O'Donnell, M., & Yusuf, S. (2021, June 1). Sodium and health: Another challenge to the current dogma. European Heart Journal. Oxford University Press. https://doi.org/10.1093/eurheartj/ehaa1093
NIH. (n.d.). What Happens to the Brain in AD? | National Institute on Aging. Retrieved October 2, 2022, from https://www.nia.nih.gov/health/what-happens-brain-alzheimers-disease
O'Donnell, M., Mente, A., Rangarajan, S., McQueen, M. J., Wang, X., Liu, L., … Yusuf, S. (2014). Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events. New England Journal of Medicine, 371(7), 612–623. https://doi.org/10.1056/nejmoa1311889
Rebello, C. J., Keller, J. N., Liu, A. G., Johnson, W. D., & Greenway, F. L. (2015, June 1). Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial. BBA Clinical. Elsevier. https://doi.org/10.1016/j.bbacli.2015.01.001
Reddy, P. H., Manczak, M., Yin, X., Grady, M. C., Mitchell, A., Tonk, S., … Author, D. (2018). Protective Effects of Indian Spice Curcumin Against Amyloid Beta in Alzheimer's Disease HHS Public Access Author manuscript. J Alzheimers Dis, 61(3), 843–866. https://doi.org/10.3233/JAD-170512
Ravnskov, U., DiNicolantonio, J. J., Harcombe, Z., Kummerow, F. A., Okuyama, H., & Worm, N. (2014, April 1). The questionable benefits of exchanging saturated fat with polyunsaturated fat. Mayo Clinic Proceedings. Elsevier Ltd. https://doi.org/10.1016/j.mayocp.2013.11.006
Rolland, Y., Pillard, F., Klapouszczak, A., Reynish, E., Thomas, D., Andrieu, S., … Vellas, B. (2007). Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial. Journal of the American Geriatrics Society, 55(2), 158–165. https://doi.org/10.1111/J.1532-5415.2007.01035.X
Roy, M., Edde, M., Fortier, M., Croteau, E., Castellano, C. A., St-Pierre, V., … Descoteaux, M. (2022). A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment. Neurobiology of Aging, 115, 77–87. https://doi.org/10.1016/J.NEUROBIOLAGING.2022.04.005
de la Rubia Ortí JE1, García-Pardo MP2, Drehmer E1, Sancho Cantus D3, Julián Rochina M4, Aguilar MA5, H. Y. I. (n.d.). Improvement of Main Cognitive Functions in Patients with AD after Treatment with Coconut Oil Enriched Mediterranean Diet: A Pilot ... - PubMed - NCBI. Retrieved April 27, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/30056419
Seneff, S., Wainwright, G., & Mascitelli, L. (2011, April 1). Nutrition and AD: The detrimental role of a high carbohydrate diet. European Journal of Internal Medicine. Elsevier B.V. https://doi.org/10.1016/j.ejim.2010.12.017
Tampi, R. R., Forester, B. P., & Agronin, M. (2021). Aducanumab: evidence from clinical trial data and controversies. Drugs in Context, 10. https://doi.org/10.7573/DIC.2021-7-3
Taylor, M. K., Sullivan, D. K., Mahnken, J. D., Burns, J. M., & Swerdlow, R. H. (2018). Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 4(1), 28–36. https://doi.org/10.1016/j.trci.2017.11.002
Woods, B., Aguirre, E., Spector, A. E., & Orrell, M. (2012). Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD005562.PUB2
Xu, Q., Zhang, Y., Zhang, X., Liu, L., Zhou, B., Mo, R., … Xue, C. (2020). Medium-chain triglycerides improved cognition and lipid metabolomics in mild to moderate AD patients with APOE4−/−: A double-blind, randomized, placebo-controlled crossover trial. Clinical Nutrition, 39(7), 2092–2105. https://doi.org/10.1016/j.clnu.2019.10.017
Zhan, X., Stamova, B., Jin, L. W., Decarli, C., Phinney, B., & Sharp, F. R. (2016). Gram-negative bacterial molecules are associated with AD pathology. Neurology, 87(22), 2324–2332. https://doi.org/10.1212/WNL.0000000000003391.